Brain scans reveal how ketamine quickly lifts severe depression

Major depressive disorder (MDD) is a major global health problem and one of the leading causes of disability. About 30% of people diagnosed with depression develop treatment-resistant depression (TRD), meaning their symptoms do not improve sufficiently with standard antidepressant medications. Ketamine has gained attention as a fast-acting antidepressant for people with TRD. However, scientists have not fully understood how it works inside the human brain, which has made it difficu...