Metformin’s hidden brain pathway revealed after 60 years

For over 60 years, metformin has been a first-line treatment for type 2 diabetes, yet scientists have not fully understood how it works. Researchers at Baylor College of Medicine, along with international collaborators, have now identified an unexpected factor behind the drug's effects: the brain. By uncovering a brain-based pathway involved in metformin's ability to lower blood sugar, the team has opened the door to more targeted and effective diabetes therapies. The findings were...