Why colorectal cancer breaks the immune system’s rules

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In most solid tumors, large numbers of regulatory T (Treg) cells are linked to worse outcomes. These immune cells normally act as brakes on the immune system, which means they can weaken the body's ability to attack cancer.

Colorectal cancer stands out as a rare and confusing exception. In this disease, tumors with more Treg cells are often associated with longer survival. For years, researchers have not understood why this pattern is so different from what is...

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